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r - Three ggplots in a 2x2 grid

Is it possible to set (with par(mfrow=()) or something else) a multiple plot panel for 3 ggplot objects, where one takes whole row and the other two are placed in second row?

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Yes you can do this using arrangeGrob / grid.arrange from gridExtra. See here To do this for your example, you'd do

library(ggplot2)
library(gridExtra)
g1 <- qplot(rnorm(10), rnorm(10))
g2 <- qplot(rpois(100, 10), geom = "histogram")
g3 <- qplot(rnorm(10))
my_plots <- list(g1, g2, g3)
my_layout <- rbind(c(1, 1), c(2, 3))
grid.arrange(grobs = my_plots, layout_matrix = my_layout)

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