You can pass custom key function to list.sort
that is used to generate the comparison key for the items:
>>> l = [[1, 5, 'e'], [1, 2, 's'], [0, 4, 'e']]
>>> l.sort(key=lambda x: (x[0], -ord(x[2])))
>>> l
[[0, 4, 'e'], [1, 2, 's'], [1, 5, 'e']]
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