You'll need to use the OleDbConnection class, as well as the OleDbCommand class, with the proper connection string for Access.
Dim sql as String = "SELECT * FROM TABLE_A WHERE COLUMN_A = @PARAM"
Dim connectionString as String = "Provider=Microsoft.Jet.OLEDB.4.0;Data Source=C:mydatabase.mdb;User Id=admin;Password=;"
Using connection As New OleDbConnection(connectionString)
Dim command As New OleDbCommand(sql)
command.Connection = connection
command.Params.Add("@PARAM", yourVariable)
connection.Open()
Dim reader As OleDbDataReader = command.ExecuteReader()
While reader.Read()
Console.WriteLine(reader.GetString(1)
End While
End Using
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