If all of the pending changelists are in different workspaces, then what you do in one doesn't (and can't) affect any of the others, unless you submit it.
If all of the pending changelists are in the same workspace, the situation is impossible in the first place; multiple pending changelists within a workspace can't all contain the same file with different changes, because only one copy of that file exists in the workspace.
与恶龙缠斗过久,自身亦成为恶龙;凝视深渊过久,深渊将回以凝视…