I found an interesting article describing how to do exactly what you are looking to do.
TL;DR: Use Shapely
You will find this code at the end of the article:
import json
from shapely.geometry import shape, Point
# depending on your version, use: from shapely.geometry import shape, Point
# load GeoJSON file containing sectors
with open('sectors.json') as f:
js = json.load(f)
# construct point based on lon/lat returned by geocoder
point = Point(-122.7924463, 45.4519896)
# check each polygon to see if it contains the point
for feature in js['features']:
polygon = shape(feature['geometry'])
if polygon.contains(point):
print 'Found containing polygon:', feature
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