You have to pass some required things in headers and use multipart/from-data content-type.
If you know about the postman then first with that and pass required headers.
files ={"message":"<messageML>Hello world!</messageML>"}
headers={
"sessionToken": "SESSION_TOKEN",
"keyManagerToken": "KEY_MANAGER_TOKEN"
}
requests.post("https://YOUR-AGENT-URL.symphony.com/agent/v4/stream/:sid/message/create", files=files,headers=headers)
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