If you declare your column with a type of timestamp, you're in clover:
>>> db = sqlite3.connect(':memory:', detect_types=sqlite3.PARSE_DECLTYPES)
>>> c = db.cursor()
>>> c.execute('create table foo (bar integer, baz timestamp)')
<sqlite3.Cursor object at 0x40fc50>
>>> c.execute('insert into foo values(?, ?)', (23, datetime.datetime.now()))
<sqlite3.Cursor object at 0x40fc50>
>>> c.execute('select * from foo')
<sqlite3.Cursor object at 0x40fc50>
>>> c.fetchall()
[(23, datetime.datetime(2009, 12, 1, 19, 31, 1, 40113))]
See? both int (for a column declared integer) and datetime (for a column declared timestamp) survive the round-trip with the type intact.
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