Do you mean column 0 and 1?
>>> df.sort([0, 1])
0 1 2 3
2 1 865545 20 20
3 1 865584 297 0
7 1 865665 296 0
9 1 865700 297 0
5 2 865628 292 5
6 10 865662 297 0
10 10 866429 297 0
8 11 865694 293 1
11 11 866438 297 0
4 22 865625 297 0
0 Z 762320 296 1
1 Z 861349 297 0
[update]
This happens if your data is not numeric (all elements are strings).
>>> df.values
array([['Z', '762320', '296', '1'],
['Z', '861349', '297', '0'],
['1', '865545', '20', '20'],
['1', '865584', '297', '0'],
['22', '865625', '297', '0'],
['2', '865628', '292', '5'],
['10', '865662', '297', '0'],
['1', '865665', '296', '0'],
['11', '865694', '293', '1'],
['1', '865700', '297', '0'],
['10', '866429', '297', '0'],
['11', '866438', '297', '0']], dtype=object)
String ordering is the expected result:
>>> df.sort([0, 1])
0 1 2 3
2 1 865545 20 20
3 1 865584 297 0
7 1 865665 296 0
9 1 865700 297 0
6 10 865662 297 0
10 10 866429 297 0
8 11 865694 293 1
11 11 866438 297 0
5 2 865628 292 5
4 22 865625 297 0
0 Z 762320 296 1
1 Z 861349 297 0
Try to convert the values first:
>>> def convert(v):
...: try:
...: return int(v)
...: except ValueError:
...: return v
>>> pandas.DataFrame([convert(c) for c in l] for l in df.values)
.sort([0, 1])
0 1 2 3
2 1 865545 20 20
3 1 865584 297 0
7 1 865665 296 0
9 1 865700 297 0
5 2 865628 292 5
6 10 865662 297 0
10 10 866429 297 0
8 11 865694 293 1
11 11 866438 297 0
4 22 865625 297 0
0 Z 762320 296 1
1 Z 861349 297 0
What is the difference? The elements are numeric now:
>>> pandas.DataFrame([convert(c) for c in l] for l in df.values)
.sort([0, 1]).values
array([[1.0, 865545.0, 20.0, 20.0],
[1.0, 865584.0, 297.0, 0.0],
[1.0, 865665.0, 296.0, 0.0],
[1.0, 865700.0, 297.0, 0.0],
[2.0, 865628.0, 292.0, 5.0],
[10.0, 865662.0, 297.0, 0.0],
[10.0, 866429.0, 297.0, 0.0],
[11.0, 865694.0, 293.0, 1.0],
[11.0, 866438.0, 297.0, 0.0],
[22.0, 865625.0, 297.0, 0.0],
['Z', 762320.0, 296.0, 1.0],
['Z', 861349.0, 297.0, 0.0]], dtype=object)