Time zones aren't built into standard Python - you need to use another library. pytz is a good choice.
>>> gmt = pytz.timezone('GMT')
>>> eastern = pytz.timezone('US/Eastern')
>>> time = "Tue, 12 Jun 2012 14:03:10 GMT"
>>> date = datetime.datetime.strptime(time, '%a, %d %b %Y %H:%M:%S GMT')
>>> date
datetime.datetime(2012, 6, 12, 14, 3, 10)
>>> dategmt = gmt.localize(date)
>>> dategmt
datetime.datetime(2012, 6, 12, 14, 3, 10, tzinfo=<StaticTzInfo 'GMT'>)
>>> dateeastern = dategmt.astimezone(eastern)
>>> dateeastern
datetime.datetime(2012, 6, 12, 10, 3, 10, tzinfo=<DstTzInfo 'US/Eastern' EDT-1 day, 20:00:00 DST>)
与恶龙缠斗过久,自身亦成为恶龙;凝视深渊过久,深渊将回以凝视…