This should be much faster than regex and you can pass a list of separators as you wanted:
def split(txt, seps):
default_sep = seps[0]
# we skip seps[0] because that's the default separator
for sep in seps[1:]:
txt = txt.replace(sep, default_sep)
return [i.strip() for i in txt.split(default_sep)]
How to use it:
>>> split('ABC ; DEF123,GHI_JKL ; MN OP', (',', ';'))
['ABC', 'DEF123', 'GHI_JKL', 'MN OP']
Performance test:
import timeit
import re
TEST = 'ABC ; DEF123,GHI_JKL ; MN OP'
SEPS = (',', ';')
rsplit = re.compile("|".join(SEPS)).split
print(timeit.timeit(lambda: [s.strip() for s in rsplit(TEST)]))
# 1.6242462980007986
print(timeit.timeit(lambda: split(TEST, SEPS)))
# 1.3588597209964064
And with a much longer input string:
TEST = 100 * 'ABC ; DEF123,GHI_JKL ; MN OP , '
print(timeit.timeit(lambda: [s.strip() for s in rsplit(TEST)]))
# 130.67168392999884
print(timeit.timeit(lambda: split(TEST, SEPS)))
# 50.31940778599528
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