def MyTestFunction(name):
    return "testing " + name

Imports IronPython.Hosting
Imports Microsoft.Scripting.Hosting

Public Class Form1
    Private Sub CallPython()
        Dim pythonPath = "D:\Code\PyTest\mytest.py"
        Dim pyruntime as ScriptRuntime = Python.CreateRuntime()
        Dim fileObj As Object = pyruntime.UseFile(pythonPath)
        Dim result = fileObj.MyTestFunction("World")
    End Sub
End Class

import os

class FileOperator:
    
    def WriteInfoToFile(self, path):
        file = open(path, "w")
        file.write("Hello World")
        file.close()

    def ReadInfoFromFile(self, path):
        fileInfo = ""
        data = open(path)
        for each_line in data:
            fileInfo += each_line
        data.close()
        return fileInfo

from mytest_common import FileOperator

def MyTestReadInfo():
    fInfo = fOperator.ReadInfoFromFile("D:\Code\PyTest\Test.txt")
    return fInfo

fOperator = FileOperator()

Imports IronPython.Hosting
Imports Microsoft.Scripting.Hosting

Public Class Form1
    Private Sub CallPython()
        Dim pythonPath = "D:\Code\PyTest\mytest.py"
        Dim pyruntime as ScriptRuntime = Python.CreateRuntime()
        Dim fileObj As Object = pyruntime.UseFile(pythonPath)
        Dim result = fileObj.MyTestReadInfo()
    End Sub
End Class

import sys
sys.path.append(".\Lib")

from mytest_common import FileOperator

def MyTestReadInfo():
    fInfo = fOperator.ReadInfoFromFile("D:\Code\PyTest\Test.txt")
    return fInfo

fOperator = FileOperator()

        public static dynamic GetPythonFileObj()
        {
            var fath = AppContext.BaseDirectory + @"Services\PythonService.py";

            var pyruntime = Python.CreateRuntime();
            var pyengine = pyruntime.GetEngine("Python");
            var paths = pyengine.GetSearchPaths();
            paths.Add(AppContext.BaseDirectory + @"Services");
            paths.Add(AppContext.BaseDirectory + @"Services\Lib");
            pyengine.SetSearchPaths(paths);

            dynamic fileObj = pyruntime.UseFile(fath);
            return fileObj;
        }


        public static string UploadTag(ref dynamic fileObj, string tagName)
        {
            var tagValue = fileObj.ex_read(tagName);
            return tagValue.ToString();
        }