this.MouseWheel += new System.Windows.Forms.MouseEventHandler(this.panel1_MouseWheel);

#region 进入窗体时加载

public FormAlarmInfoQuery()
{
	InitializeComponent();
	pictureBox1.ImageLocation = "f:\\1.jpg";

         this.MouseWheel += new System.Windows.Forms.MouseEventHandler(this.panel1_MouseWheel);
         //判断是否已安装带滚轮的鼠标
	//SystemInformation.MouseWheelPresent.ToString();
	//获取鼠标滚轮在滚动时所获得的行数
	//SystemInformation.MouseWheelScrollLines.ToString();
	//判断该操作系统是否支持滚轮鼠标
	//SystemInformation.NativeMouseWheelSupport.ToString(); 
}

#endregion

然后写一个鼠标事件方法

private void panel1_MouseWheel(object sender, System.Windows.Forms.MouseEventArgs e)
{
	MessageBox.Show("滚动事件已被捕捉");
	System.Drawing.Size t = pictureBox1.Size;
	t.Width += e.Delta;
	t.Height += e.Delta;
	pictureBox1.Width = t.Width;
	pictureBox1.Height = t.Height;
}

如果输出了“滚动事件已被捕捉”，那么鼠标滚轮事件就成功被捕捉了，就可以在在里边写让鼠标滚轮处理的事件了