Try this code
Microsoft.Office.Interop.Excel.Application oXL;
Microsoft.Office.Interop.Excel._Workbook oWB;
Microsoft.Office.Interop.Excel._Worksheet oSheet;
Microsoft.Office.Interop.Excel.Range oRng;
object misvalue = System.Reflection.Missing.Value;
try
{
//Start Excel and get Application object.
oXL = new Microsoft.Office.Interop.Excel.Application();
oXL.Visible = true;
//Get a new workbook.
oWB = (Microsoft.Office.Interop.Excel._Workbook)(oXL.Workbooks.Add(""));
oSheet = (Microsoft.Office.Interop.Excel._Worksheet)oWB.ActiveSheet;
//Add table headers going cell by cell.
oSheet.Cells[1, 1] = "First Name";
oSheet.Cells[1, 2] = "Last Name";
oSheet.Cells[1, 3] = "Full Name";
oSheet.Cells[1, 4] = "Salary";
//Format A1:D1 as bold, vertical alignment = center.
oSheet.get_Range("A1", "D1").Font.Bold = true;
oSheet.get_Range("A1", "D1").VerticalAlignment =
Microsoft.Office.Interop.Excel.XlVAlign.xlVAlignCenter;
// Create an array to multiple values at once.
string[,] saNames = new string[5, 2];
saNames[0, 0] = "John";
saNames[0, 1] = "Smith";
saNames[1, 0] = "Tom";
saNames[4, 1] = "Johnson";
//Fill A2:B6 with an array of values (First and Last Names).
oSheet.get_Range("A2", "B6").Value2 = saNames;
//Fill C2:C6 with a relative formula (=A2 & " " & B2).
oRng = oSheet.get_Range("C2", "C6");
oRng.Formula = "=A2 & " " & B2";
//Fill D2:D6 with a formula(=RAND()*100000) and apply format.
oRng = oSheet.get_Range("D2", "D6");
oRng.Formula = "=RAND()*100000";
oRng.NumberFormat = "$0.00";
//AutoFit columns A:D.
oRng = oSheet.get_Range("A1", "D1");
oRng.EntireColumn.AutoFit();
oXL.Visible = false;
oXL.UserControl = false;
oWB.SaveAs("c:\test\test505.xls", Microsoft.Office.Interop.Excel.XlFileFormat.xlWorkbookDefault, Type.Missing, Type.Missing,
false, false, Microsoft.Office.Interop.Excel.XlSaveAsAccessMode.xlNoChange,
Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing);
oWB.Close();
oXL.Quit();
//...
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