The title is pretty clear: Is there any major difference between innerHTML and createTextNode (used with Append) to fill a span with text?
innerHTML
createTextNode
Append
Of course. createTextNode will escape any strings and show them as they are, while innerHTML could render html-like strings into a DOM. If you don't want that (unless you are sure the text contains no unescaped tags, e.g. when assigning a literal directly), you can use textContent (or innerText for IE).
textContent
innerText
Yet I'd recommend createTextNode, because all browsers support it equally without any quirks.
2.1m questions
2.1m answers
60 comments
56.9k users