Do not use a singleton for something that might evolve into a multipliable resource.
This probably sounds silly, but if you declare something a singleton you're making a very strong statement that it is absolutely unique. You're building code around it, more and more. And when you then find out after thousands of lines of code that it is not a singleton at all, you have a huge amount of work in front of you because all the other objects expect "the" sacred object of class WizBang to be a singleton.
Typical example: "There is only one database connection this application has, thus it is a singleton." - Bad idea. You may want to have several connections in the future. Better create a pool of database connections and populate it with just one instance. Acts like a Singleton, but all other code will have growable code for accessing the pool.
EDIT: I understand that theoretically you can extend a singleton into several objects. Yet there is no real life cycle (like pooling/unpooling) which means there is no real ownership of objects that have been handed out, i.e. the now multi-singleton would have to be stateless to be used simultaneously by different methods and threads.
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